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Laser Doppler Imaging moorLDI2-IR

Large area, high resolution blood flow laser Doppler imaging 

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产品简介

Large area, high resolution blood flow laser Doppler imaging 


The moorLDI2-IR laser Doppler blood flow imager offers a well proven, high specification solution to your blood flow application for clinical or research application. The system is in routine use in numerous laboratories and clinics globally and employs unique, optical design and signal processing in order to generate the highest resolution and clearest images of its class.

Laser Doppler imaging (LDI) is often compared to laser speckle imaging and whilst there are some similarities, both techniques offer unique advantages. LDI generally offers deeper penetration enabling enhanced visualisation of small vessels below the tissue surface, perfect for angiogenesis modelling or through skull pre clinical cerebral blood flow imaging.

moorLDI2-IR also allows very large area imaging – up to 50cm x 50cm in one scan. For certain applications these features are critical.

Other features and benefits include;

  •  Non contact measurement – painless for patient, aids infection control, no chemical tracers or dyes needed.
  •  Daylight operation – use in most lab, clinic or theatre settings.
  •  Flexible scan sizes – from a fingertip up to an adult torso.
  •  High spatial resolution – to catch the finest detail to 100 micron.
  •  Single and Repeat imaging modes – compare flow from region to region within the same scan and scan the same region repeatedly to assess changes over time.
  •  Advanced Windows compatible software – to ease setup and scanning. Post Measurement processing functions to make the most of your data.
  •  Protocol control – set the imager to control flexible tissue heating, pressure cuff control and transdermal drug delivery routines - reproducible, precise and reliable.
  •  Digital Trigger In/ Out – to synchronise with external devices.
  •  Digital Signal Processing and High Quality optics – providing the highest sensitivity to changes in blood flow and superb reliability.
  •  Choice of lasers – to assess from the surface to superficial and deeper tissue beds.
  •  Choice of stands – for benchtop and clinical/ theatre use.


There are numerous references where the moorLDI2 is cited. The list below is a small selection. Please contact us for reference lists on your chosen subject.

Abraham, A., Alabdali, M., Alsulaiman, A., Breiner, A., Barnett, C., Katzberg, H.D., Lovblom, L.E., Perkins, B.A., Bril, V., (2016).Laser Doppler Flare Imaging and Quantitative Thermal Thresholds Testing Performance in Small and Mixed Fiber Neuropathies.Plos One, 11(11), ppe0165731.


Campos-Junior, P. H. A., Alves, T. J. M., Dias, M. T., Assunçao, C. M., Munk, M., Mattos, M. S., Kraemer, L. R., Almeida, B. G., Russo, R. C., Barcelos, L., Camargo, L. S. A., and Viana, J. H. M., (2016).Ovarian Grafts 10 Days after Xenotransplantation: Folliculogenesis and Recovery of Viable Oocytes.PLoS ONE 11(6): e0158109. doi:10.1371/journal.pone.0158109.


Chalothorn, D., Clayton, J .A, Zhang, H., Pomp , D., and Faber, J. E., (2007).Collateral density, remodeling, and VEGF-A expression differ widely between mouse strains.Physiological genomics, 30(2), pp.179–91.


Datta , D., Ferrell, W . R., Sturrock , R . D., Jadhav , S . T., and Sattar , N., (2007).Inflammatory suppression rapidly attenuates microvascular dysfunction in rheumatoid arthritis.Atherosclerosis, 192(2), pp.391–5.


De, P., Peng , Q., Traktuevc, D . O., Li , W., Yoder, M . C., March, K . L., Durden, D . L. (2009).Expression of RAC2 in endothelial cells is required for the postnatal neovascular response.Experimental Cell Research, 315(2), pp.248–263.


Dimitroulas, T., Sandoo, A., Hodson, J., Smith, J. P., and Kitas, G. D., (2016).In vivo microvascular and macrovascular endothelial function is not associated with circulating dimethylarginines in patients with rheumatoid arthritis: a prospective analysis of the DRACCO cohort.Scand J Clin Lab Invest, 76(4), pp:331-7.


Ebadi, H., Perkins, B . a, Katzberg, H . D., Lovblom, L . E., Bril, V.,(2012).Evaluation of proxy tests for SFSN: evidence for mixed small and large fiber dysfunction.PloS one, 7(8), p.e42208.


Edmunds, MC., Wigmore, S., Kluth, D., (2013).In situ transverse rectus abdominis myocutaneous flap: a rat model of myocutaneous ischemia reperfusion injury.J Vis Exp. 2013 Jun 8;(76). www.jove.com/video/50473/in-situ-transverse-rectus-abdominis-myocutaneous-flap-rat-model


Gil, C. H., Ki, B. S., Seo, J., Choi, J. J., Kim, H., Kim, I. G., Jung, A. R., Lee, W-Y., Choi, Y., Park, K., Moon, S-H., and Chung, H-M., (2016).Directing human embryonic stem cells towards functional endothelial cells easily and without purification.Tissue Engineering and Regenerative Medicine. 13(3), pp:274–283.


Gorodkin, R., Herrick, A. L., and Murray, A. K., (2016).Microvascular response in patients with complex regional pain syndrome as measured by laser Doppler imaging.Microcirculation, 23(5), pp:379-83.


Gunawardena, H., Harris, N . D., Carmichael, C., McHugh, N . J., (2007a).Maximum blood flow and microvascular regulatory responses in systemic sclerosis.Rheumatology (Oxford, England), 46(7), pp.1079–82.


Gunawardena, H., Harris, N . D., Carmichael, C., McHugh, N . J., (2007b).Microvascular responses following digital thermal hyperaemia and iontophoresis measured by laser Doppler imaging in idiopathic inflammatory myopathy.Rheumatology (Oxford, England), 46(9), pp.1483–6.


Hsieh, M.J., Liu, H.T., Wang, C.N., Huang, H.Y., Lin, Y., Ko, Y.S., Wang, J.S., Chang, V.H., and Pang, J.S., (2016).Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation.J Mol Med (Berl), Nov 15.[Epub ahead of print].


Isenberg, J . S., Maxhimer , J . B., Powers, P., Tsokos, M ., Frazier, W . a, Roberts , D . D., (2008).Treatment of liver ischemia-reperfusion injury by limiting thrombospondin-1/CD47 signaling.Surgery, 144(5), pp.752–61.


Isenberg , J . S., Shiva, S., Gladwin, M., (2009).Thrombospondin-1-CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood flow and angiogenesis via coupled NO-cGMP pathway activation.Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society, 21(1), pp.52–62.


Khoo, T . L., Halim, a S., Zakaria, Z., Mat Saad, a Z., Wu, L . Y., Lau, H . Y.,(2011).A prospective, randomised, double-blinded trial to study the efficacy of topical tocotrienol in the prevention of hypertrophic scars. Journal of plastic, reconstructive & aesthetic surgery :JPRAS, 64(6), pp.e137–45.


Krishnan, S . T., Quattrini, C., Jeziorska M., Malik, R.A., Rayman, G., (2007).Neurovascular Factors in Wound Healing in the Foot Skin of Type 2 Diabetic Subjects.DIABETES CARE,, 30(12), pp.3058 – 3062.


Kvietys, P., Granger, D., (2012).Role of reactive oxygen and nitrogen species in the vascular responses to inflammation.Free Radical Biology and Medicine, 52(3), pp.556–592.


Jensen, A. R., Manning, M. M., Khaneki, S., Drucker, N. A., and Markel, T. A., (2016).Harvest Tissue Source Does Not Alter the Protective Power of Stromal Cell Therapy Following Intestinal Ischemia and Reperfusion Injury.Journal of SurgicalResearch, 204(2), pp:361-370.


Lasch, M., Caballero-Martinez, A., Troidl, K., Schloegl, I., Lautz, T., and Deindl, E., (2016).Arginase inhibition attenuates arteriogenesis and interferes with M2 macrophage accumulation.Lab Invest. 2016 May 30, doi: 10.1038/labinvest.2016.62. [Epub ahead of print].


Lee, J. H., Ryu, J. M., Han, Y. S., Zia, M. F., Kwon, H. Y., Noh, H., Han, H. J., and Lee, S. H., (2016).Fucoidan improves bioactivity and vasculogenic potential of mesenchymal stem cells in murine hind limb ischemia associated with chronic kidney disease.J Mol Cell Cardiol, 97, pp:169-17.


Lohman , B., (2007).The effect of whole body vibration on lower extremity skin blood flow in normal subjects.Med Sci …, 13(2).


Marks, D. J. B., Harbord, M . W. N., Macallister, R., Rahman, F . Z., Young , J., Al-lazikani, B., Lees, W., Novelli, M., Bloom, S., Segal, A . W., (2006).Defective acute inflammation in Crohn’s disease : a clinical investigation.Lancet, 367.


Nabavi Nouri, M., Ahmed, A., Bril, V., Orszag, A., Ng, E., Nwe, P., Perkins, B . a, (2012).Diabetic neuropathy and axon reflex-mediated neurogenic vasodilatation in type 1 diabetes.PloS one, 7(4), p.e34807.


Oda, M., Toba, K., Ozawa, T., Kato, K., Yanagawa, T., Ikarashi, N., Takayama, T., Suzuki, T., Hanawa, H., Fuse, I., Nakata, K., Narita, M., Takahashi, M., Aizawa, Y., (2010).Establishment of culturing system for ex-vivo expansion of angiogenic immature erythroid cells, and its application for treatment of patients with chronic severe lower limb ischemia.Journal of molecular and cellular cardiology, 49(3), pp.347–53.


Pinto, N.C., Cassini-Vieira, P., de Souza-Fagundes, E.M., Barcelos, L.S., Nogueira Castañon, M.C., and Scio, E., 2016.Pereskia aculeata Miller leaves accelerate excisional wound healing in mice.J Ethnopharmacol., Sep 3. [Epub ahead of print].


Silva, L.P., Pirraco, R.P., Santos, T.C., Novoa-Carballal, R., Cerqueira, M.T.,2, Reis R.L., Correlo, V.M., and Marques, A.P., (2016).Neovascularization Induced by the Hyaluronic Acid-Based Spongy-Like Hydrogels Degradation Products.ACS Appl Mater Interfaces, 8(49). pp33464-33474.


Terkelsen, A. J., Bach, F. W., Jensen, T . S., (2009).Experimental forearm immobilization in humans reduces capsaicin-induced pain and flare.Brain research, 1263, pp.43–9.


Tsatralis, T., Ridiandries, A., Robertson, S., Vanags, L.Z., Lam, Y.T., Tan, J.T.M., Ng, M.K.C., and Bursill, C.A., 2016.Reconstituted high-density lipoproteins promote wound repair and blood flow recovery in response to ischemia in aged mice.Lipids in Health and Disease . 15(1), pp150-161.


Vasam, G., Joshi, S., Jarajapu, Y. P. R., (2016).Impaired Mobilization of Vascular Reparative Bone Marrow Cells in Streptozotocin-Induced Diabetes but not in Leptin Receptor-Deficient db/db Mice.Scientific Reports 6(26131), pp:1-13.


Wajima, D., Nakamura, M., Horiuchi, K., Miyake, H., Takeshima, Y., Tamura, K., Motoyama, Y., Konishi, N., Nakase, H., (2010).Enhanced cerebral ischemic lesions after two-vein occlusion in diabetic rats.Brain research, 1309, pp.126–35.


Wester, T., Häggblad, E., (2011).Assessments of skin and tongue microcirculation reveals major changes in porcine sepsis.Clinical Physiology


Winchester, L., Chou,N ., (2008).Measurement of sublingual blood velocity as a tool for monitoring sepsis.Engineering in Medicine and …, (1), pp.3739–3742.


Yang, Y., Chen, Z., Zhang, T., Wang, S., and Qing, Y., (2016).Wnt3a promoted the therapeutic of angiogenesis on lower leg ischemia with endothelial progenitor cells.Int J Clin Exp Med, 9(3), pp:5902-5911.


Zeng, L., Xiao, Q., Chen, M., Margariti, A., Martin, D., Ivetic, A., Xu, H., Mason, J., Wang, W., Cockerill, G., Mori, K., Li, J . Y., Chien, S., Hu, Y., Xu, Q., (2013).Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis.Circulation, 127(16), pp.1712–22.


Zhao, Y., Li, Y., Luo, P., Gao, Y., Yang, J., Lao, K-H., Wang, G., Cockerill, G., Hu, Y., Xu, Q., Li, T., and Zeng, L., (2016).XBP1 splicing triggers miR-150 transfer from smooth muscle cells to endothelial cells via extracellular vesicles.Sci. Rep. 6, 28627.


          

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