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Aurora 离体肌肉测试系统(1200A 1205A)

测量离体肌肉,束状和条状组织的力学性能

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产品简介

测量离体肌肉,束状和条状组织的力学性能



一个行业领先且简便易用的测试系统:测量离体肌肉,束状和条状组织的力学性能

1200A1205A离体肌肉测试系统是量化离体肌肉力学性能的领先科技。这两个系统可进行测量的样本分别有:趾长伸肌、胫骨前肌、 比目鱼肌、 腓肠肌、 横隔膜肌、细小肌肉(如屈趾长肌和蚓状肌),甚至是一些人造组织, 聚合物或者是薄膜。

静息长度,静息力度,刺激等参数和进行实验的方案都可以通过控制软件(DMC)设置。电脑桌面也会提供标准实验方案的扩充程式库,方案包括: 抽搐张力,强直收缩张力,疲劳,力-刺激频率,力-收缩速率,硬度和功循环等。

系统针对小鼠或大鼠有其专属的平台装置,装置配有可外层注水的溶液瓶和供氧配置。另外,系统更包括Aurora Scientific的旗舰双模肌肉杠杆系统,高能刺激器,数据采集硬件,安装在客制电脑主机的控制和分析软件。实验前操作准备,数据采集和数据分析都能通过我们的控制和分析软件(DMC/DMA)在数分钟内完成。

实验装置可以让研究者调整浴瓶的位置以便於样本连结过程的操作。此外,双模肌肉杠杆系统的的双模传感器,不仅能测量力度和长度,同时也有控制力度和长度的能力,在这个基础上,肌肉样本和双模传感器之间只需要一个连接点,大幅减省了实验操作时程,同时也提高了数据生产率。选择1200A1205A,体验系统在您的研究进展中带来高性能和高精准的表现。



* 在一个系统的基础上,可以组合测试小鼠和大鼠的配置

一站式的离体实验设备

离体肌肉测量的领军技术

高速的数据采集和分析软件: 用於Windows 操作系统

简便的组装和操作,能够根据您测量需求的改变而进行扩充

能够进行更多复杂且多方面测量的方案

* 测量力度峰值可达10N(1000g)


1200A – Easy to Use System Is an Invaluable Tool for Lab
CHALLENGE
In 2013 Aurora Scientific was approached by Dr. Espen Spangenburg at the University of Maryland about our 1200A test system for working with isolated EDL and soleus muscle taken from mice. Dr. Spangenburg studied the mechanisms of muscle metabolism and intended to make use of in-vitro techniques to perform his research. While Dr. Spangenburg was familiar with these types of experiments from his work with similar home built equipment used in graduate school, he needed something easy to use and reliable for his own lab.

SOLUTION
Though the system was essentially a standard configuration, the 1200A proved that it is an easy to use, turnkey system for measuring mechanics of intact excised muscle. Aurora Scientific provided Dr. Spangenburg with a robust, accurate system that was capable of being configured to fit his specific needs. The system was engineered to include an adjustable tissue bath and mounts to simplify experimental setup. In addition, we included our flagship Dual-Mode muscle lever enabling the control of both force and length for a gamut of experimental protocols. Aurora Scientific provided further technical support to Dr. Spangenburg’s students covering software use and best practices for using the system.

RESULTS
Dr. Spangenburg was easily able to set up and configure the equipment to his lab’s needs and obtained high quality contractile data immediately with the first muscle tested using the system. The ability to adjust the tissue bath and mounts to suit their needs provided an avenue for straightforward tissue attachment and Lo measurement for accurate and reproducible experimentation. Control and measurement of force and length allowed the lab to go beyond isometric measurement to test more complex muscle mechanics, such as eccentric and concentric contractions. The test system proved to be easy to use by both professor and student alike and was used by the lab for several subsequent studies. The 1200A enabled them to expand their research resulting in a number of publications and remains an essential piece of equipment for the lab to date.


Mitchell, Andrew S. et al. “Functional, morphological, and apoptotic alterations in skeletal muscle of ARC deficient mice.” 
Apoptosis 20.3 (2015): 310-326.

Moorwood, Catherine et al. “Isometric and eccentric force generation assessment of skeletal muscles isolated from murine models of muscular dystrophies.” Journal of Visualized Experiments 71 (2013): e50036-e50036.

Pinniger, Gavin J. et al. “Skeletal muscle weakness caused by carrageenan-induced inflammation.” Muscle & Nerve 46.3 (2012): 413-420.

de Man, Frances S. et al. “Diaphragm muscle fiber weakness in pulmonary hypertension.” American Journal of Respiratory and Critical Care Medicine 183.10 (2011): 1411-1418.

Ramsey, Kathryn A. et al. “Fiber-type dependence of stretch-induced force enhancement in rat skeletal muscle.” Muscle & Nerve 42.5 (2010): 769-777.

Labeit, Siegfried et al. “Modulation of Muscle Atrophy, Fatigue and MLC Phosphorylation by MuRF1 as Indicated by Hindlimb Suspension Studies on MuRF1-KO Mice.” Journal of Biomedicine and Biotechnology 2010 (2010): 1-9.

Ottenheijm, Coen A.C. et al. “Altered contractility of skeletal muscle in mice deficient in titin's M-band region.” Journal of Molecular Biology 393.1 (2009): 10-26.


Ramsey, Kathryn A. et al. “Fiber-type dependence of stretch-induced force enhancement in rat skeletal muscle.” Muscle & Nerve 42.5 (2010): 769-777.

Labeit, Siegfried et al. “Modulation of Muscle Atrophy, Fatigue and MLC Phosphorylation by MuRF1 as Indicated by Hindlimb Suspension Studies on MuRF1-KO Mice.” Journal of Biomedicine and Biotechnology2010 (2010): 1-9.

Ottenheijm, Coen A.C. et al. “Altered contractility of skeletal muscle in mice deficient in titin's M-band region.” Journal of Molecular Biology 393.1 (2009): 10-26.



          

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