Aurora科学测量仪器一直是全球领先科学研究人员的选择。我们选择的双模式杠杆系统和力传感器用于广泛的生命科学研究专业,包括运动和代谢,心脏病学,损伤恢复,老年病学,疾病进展,药理学等。我们的快速响应传感器被认为是研究气味动力学和信息素/羽流分散的嗅觉研究的基准仪器,我们的机械刺激器技术被用于研究神经元对触摸,疼痛和伸展的反应。许多仪器也被材料科学研究人员用于研究人造肌肉,运动和纳米材料的特性​  .....

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首页    Aruora    300C-I:机械刺激器

300C-I:机械刺激器

300C-I机械刺激器是一种自动化的von Frey电子设备,具有在单个应用点测量和控制力和长度的额外功能。300C-I消除了手持von Frey细丝或其他手持机械刺激器施加力的可变性和笨拙性
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产品简介  

300C-I机械刺激器是一种自动化的电子von Frey设备,具有在单一应用点测量和控制力和长度的附加功能。300C-I消除了使用手持式Von Frey灯丝或其他手持式机械刺激器施力时的可变性和笨拙性。我们的计算机控制的机械刺激器消除了与von Frey灯丝和其他电子von Frey系统相关的不可避免的手部颤抖。这就消除了相关的施力变化。

Aurora Scientific的机械刺激器消除了为确定阈值而进行多次测试的需要,从而提高了产量。刺激的施力和时间是一致和精确的,从而消除了与手持设备有关的变化。

机械刺激器能够在预先设定的时间段内施加恒定的力,并具有按预先确定的速率调整力的附加功能。刺激可以以长度或力的任何组合来应用,并可以遵循任意的力或距离应用曲线,因此力的应用不限于简单的力的斜坡。

恒定和可重复的力的传递确保了实验、受试者和研究之间的一致性,从而减少了数据中可避免的错误,提高了研究结果的质量。

产品特点

用计算机控制的刺激来量化机械敏感度
评估超阈值的机械敏感性
无需进行多次测试即可测量机械阈值
最大限度地减少离轴力

有一系列的针尖(0.5、0.8、1、1.5、2、3毫米直径)可供选择

在整个力的范围内,应用区域保持不变

力的范围。0.5N - 10N
优异的分辨率(达到0.3mN)
在任何方向操作

参考论文

Kumar, Siddarth. et al. “Viscoelastic characterization of the primate finger pad in vivo by microstep indentation and three-dimensional finite element models for tactile sensation studies .” Journal of Biomechanical Engineering (2015) DOI: 10.1115/1.4029985

Schwaller et al. “USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans” Nature Neuroscience (2021) DOI: 10.1038/s41593-020-00751-y

Schwaller et al. “USH2A is a Meissner’s corpuscle protein necessary for normal vibration sensing in mice and humans” Nature Neuroscience (2021) DOI: 10.1038/s41593-020-00751-y

Bove, Geoffrey M., Daniel R. Robichaud, and Peter Grigg. “Three-dimensional load analysis of indentation stimulators.” Journal of Neuroscience Methods (2003) DOI: 10.1016/s0165-0270(02)00326-6

Molliver, Derek C. et al. “The ADP receptor P2Y1 is necessary for normal thermal sensitivity in cutaneous polymodal nociceptors.” Molecular Pain (2011) DOI: 10.1186/1744-8069-7-13

Luu et al. “Modulation of SUR1 KATP Channel Subunit Activity in the Peripheral Nervous System Reduces Mechanical Hyperalgesia after Nerve Injury in Mice” International Journal of Molecular Science (2019) DOI: 10.3390/ijms20092251

Neubarth et al. “Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception” Science (2020) DOI: 10.1126/science.abb2751

Dieudonné, Alexandre et al. “Encoding properties of the mechanosensory neurons in the Johnston’s organ of the hawk moth, Manduca sexta.” The Journal of Experimental Biology (2014) DOI: 10.1242/jeb.101568

Khalsa, Partap S., Ce Zhang, and Yi-Xian Qin. “Encoding of location and intensity of noxious indentation into rat skin by spatial populations of cutaneous mechano-nociceptors.” Journal of Neurophysiology (2000) DOI: 10.1152/jn.2000.83.5.3049

Ge, Weiqing, and Partap S. Khalsa. “Encoding of compressive stress during indentation by group III and IV muscle mechano-nociceptors in rat gracilis muscle.” Journal of Neurophysiology (2003) DOI: 10.1152/jn.00624.2002

Reed, Jamie L. et al. “Effects of spatiotemporal stimulus properties on spike timing correlations in owl monkey primary somatosensory cortex.” Journal of Neurophysiology (2012) DOI: 10.1152/jn.00414.2011

Jankowski, Michael P. et al. “Dynamic changes in heat transducing channel TRPV1 expression regulate mechanically insensitive, heat sensitive C-fiber recruitment after axotomy and regeneration.” The Journal of Neuroscience (2012) DOI: 10.1523/JNEUROSCI.3148-12.2012

Zhao and Levy “Dissociation between CSD-Evoked Metabolic Perturbations and Meningeal Afferent Activation and Sensitization: Implications for Mechanisms of Migraine Headache Onset” The Journal of Neuroscience (2018) DOI: 10.1523/JNEUROSCI.0115-18.2018

Grayson et al. “Depiction of Oral Tumor-Induced Trigeminal Afferent Responses Using Single-Fiber Electrophysiology” Scientific Reports (2019) DOI: 10.1038/s41598-019-39824-9

Qi, Huixin et al. “Cortical neuron response properties are related to lesion extent and behavioral recovery after sensory loss from spinal cord injury in monkeys.” The Journal of Neuroscience (2014) DOI: 10.1523/JNEUROSCI.4954-13.2014

Milenkovic, Nevena et al. “A somatosensory circuit for cooling perception in mice.” Nature Neuroscience (2014) DOI: 10.1038/nn.3828

 

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